The San Francisco 49ers dropped their first NFC West matchup of the year, falling 27-14 to the Los Angeles Rams on the road.

A 10-point lead and a masterclass from Jauan Jennings were wasted away by the 49ers as they collapsed in the fourth quarter ...

Kyle Shanahan ...

Coach Kyle Shanahan didn't appear concerned about former QB Jimmy Garoppolo's knowledge of the 49ers giving the Los Angeles ...

NFC West foes San Francisco and Los Angeles face off again on Sunday. Here's what to know about one of the oldest rivalries ...

Injuries are an inherent part of the game of football, and the San Francisco 49ers are feeling the effects as they prepare ...

The 49ers have listed George Kittle as doubtful to play this Sunday against the Los Angeles Rams. That means backup tight end ...

Running back Isaac Guerendo is fast. And he's big. But the San Francisco 49ers rookie is a work in progress. His lone carry ...

The San Francisco 49ers head to Southern California to take on the division-rival Los Angeles Rams on Sunday. They do so with ...

The recent retirement of Aaron Donald, the three-time Defensive Player of the Year and a key figure in the Rams' defense, has ...

Suddenly in doubt for the Week 3 game at L.A. are tight end George Kittle, defensive end Nick Bosa, and cornerback Charvarius ...

Head coach Kyle Shanahan shared the final injury report ahead of the 49ers Week 3 matchup and discussed the team's ...