eLife4h
Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy
A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.
eLife21h
Prophage regulation of Shewanella fidelis 3313 motility and biofilm formation: implications for gut colonization dynamics in Ciona robusta
Dept Pediatrics, Morsani College of Medicine, University of South Florida, Tampa FL, United States ...
eLife21h
Decoding Liver Cancer Prognosis: From Multi-omics Subtypes, Prognostic Models to Single Cell Validation
This manuscript offers valuable insights by identifying two distinct liver cancer subtypes through multi-omics integration and developing a robust prognostic model, validated across various datasets, ...
eLife21h
SICKO: Systematic Imaging of Caenorhabditis Killing Organisms
This work describes a valuable method, SICKO, for real-time longitudinal quantification of bacterial colonization in the gut of individual C. elegans. The authors present convincing evidence to ...
eLife21h
Advantageous and disadvantageous inequality aversion can be taught through vicarious learning of others’ preferences
This cost looms even larger when one can benefit from an unequal distribution of resources, a phenomenon known as advantageous inequity—for example, receiving a higher salary than a colleague with the ...
eLife3d
A florigen-expressing subpopulation of companion cells expresses other small proteins and reveals a nitrogen-sensitive FT repressor
The authors demonstrated cellular heterogeneity of companion cells (CCs) and also suggested the CC subpopulation that highly expressed the florigen gene FT. Based on this finding, they further ...
eLife3d
NR2F2 is required in the embryonic testis for Fetal Leydig Cell development
This important study reveals a critical role of the transcription factor NR2F2 in mouse fetal Leydig cell (FLC) differentiation. With elegantly carried out experiments, the authors provide compelling ...
eLife3d
An increase in reactive oxygen species underlies neonatal cerebellum repair
This important work substantially advances our understanding of reactive oxygen species (ROS) as a regenerative signal during postnatal cerebellum repair by activating adaptive progenitor ...
eLife4d
Capsular Polysaccharide Restrains Type VI Secretion in Acinetobacter baumannii
The type VI secretion system (T6SS) is a sophisticated, contact-dependent nanomachine involved in interbacterial competition. To function effectively, the T6SS must penetrate the membranes of both ...
eLife4d
Mechanical imbalance between normal and transformed cells drives epithelial homeostasis through cell competition
Cell competition in epithelial tissue eliminates transformed cells expressing activated oncoproteins to maintain epithelial homeostasis. Although the process is now understood to be of mechanochemical ...
eLife4d
Reconstruction of functional olfactory sensory tissue from embryonic nasal stem cells
During the development of the olfactory epithelium (OE), olfactory sensory neurons (OSNs) express only one member of the odorant receptor (OR) gene family, and O ...
eLife6d
DNA replication in primary hepatocytes without the six-subunit ORC
Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. The origin recognition ...