Christian McCaffrey is one of the most exciting players on the San Francisco 49ers roster. The 28-year-old star, who was traded from the Carolina Panthers during the 2022-23 season, has had a huge impact on Kyle Shanahan's roster.

"Nobody knows" when Christian McCaffrey will be ready to return from injured reserve, 49ers coach Kyle Shanahan said Sunday.

San Francisco 49ers star Christian McCaffrey could miss more than the minimum of four games required on injured reserve, according to multiple reports.

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And they’ve played games without Christian McCaffrey in the last year and a half.

The San Francisco 49ers are without running back Christian McCaffrey for at least four weeks. A report from NFL Media’s Ian Rapoport indicates it could be longer than that. Rapoport on Sunday morning reported McCaffrey is expected to be out at least six weeks —

San Francisco 49ers running back Christian McCaffrey missed most of training camp and the entire preseason due to a calf strain and Achilles tendinitis,

The San Francisco 49ers have ruled out Christian McCaffrey for Week 2 vs. the Minnesota Vikings — and potentially longer.

George Kittle missed practice on Thursday because of a hamstring injury. Here's the latest on the TE's status for the Week 3 49ers vs. Rams game.

The San Francisco 49ers will face the Los Angeles Rams on Sunday without wide receiver Deebo Samuel and running back Christian McCaffrey. Samuel sustained a calf strain in Sunday's game against the Minnesota Vikings,

San Francisco 49ers head coach Kyle Shanahan confirms that the injury to running back Christian McCaffrey is not expected to keep him out for the long term.