Isaac Guerendo speaks to the media after San Francisco's 47-24 loss to the Arizona Cardinals to reflect on his rookie season.49ers Guerendo shares injury concern, reflects on rookie season originally ...

Rookie running back Isaac Guerendo was carted off the field less than two minutes into the first quarter during the 49ers’ ...

San Francisco running back Isaac Guerendo exited the 49ers' season finale versus the Arizona Cardinals just four plays into ...

San Francisco 49ers QB Joshua Dobbs and LB Fred Warner reacted to the 49ers season finale against the Arizona Cardinals.

San Francisco 49ers running back Isaac Guerendo was carted off the field in the first quarter against the Arizona Cardinals.

The 49ers fear RB Isaac Guerendo suffered an MCL injury against the Cardinals in Week 18. Kyle Shanahan provides several injury updates from the game.

Unfortunately, San Francisco 49ers' running back Isaac Guerendo was carted off the field early in the first quarter.

Rookie running back Isaac Guerendo was carted off the field early in the 49ers’ season finale in Arizona against the ...

San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has ...

San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers ‘ season finale versus the ...

The 49ers have running backs Christian McCaffrey (knee), Elijah Mitchell (hamstring) and Jordan Mason (ankle) on injured reserve, which elevated Guerendo to the starting role Dec. 8. They have started ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 against the Arizona Cardinals. Rookie Isaac Guerendo went down on the fourth ...