Christian McCaffrey is one of the most exciting players on the San Francisco 49ers roster. The 28-year-old star, who was ...

The San Francisco 49ers head to Southern California to take on the division-rival Los Angeles Rams on Sunday. They do so with ...

Head coach Kyle Shanahan shared the final injury report ahead of the 49ers Week 3 matchup and discussed the team's ...

San Francisco 49ers star tight end George Kittle missed his second straight practice on Friday as ESPN insider Adam Schefter ...

The San Francisco 49ers suddenly have a host of injury problems, and it's reflected on their second practice report of ...

Now comes the hard part for Kyle Shanahan — devising a game plan without Deebo Samuel and Christian McCaffrey.

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...

The San Francisco 49ers won’t have wide receiver Deebo Samuel for a couple weeks because of a calf injury he sustained late ...

Head coach Kyle Shanahan discussed running San Francisco's offense without RB Christian McCaffrey and WR Deebo Samuel Sr., ...

Now comes the hard part for Kyle Shanahan — devising a game plan without Deebo Samuel and Christian McCaffrey.

The San Francisco 49ers officially have a significant injury problem on their hands. Running back Christian McCaffrey is out ...

The parents of Kyle Shanahan and Christian McCaffrey recalled their experiences leading up to the star running back's trade ...