SportsLine's model simulated Los Angeles Rams vs. San Francisco 49ers 10,000 times and made its Week 3 NFL picks, predictions ...

Tight end George Kittle will not play in Sunday’s game against the Los Angeles Rams, the team announced Saturday. Kittle has ...

There is an NFC West contest on Sunday, Sept. 22 between the San Francisco 49ers and the Los Angeles Rams at SoFi Stadium in ...

Thrust into the eye of an injury hurricane, 49ers’ quarterback Brock Purdy is poised to show all the doubters, naysayers and ...

The San Francisco 49ers vs. Los Angeles Rams game will be played today. Both teams are coming off Week 2 losses and hope to ...

NFC West foes San Francisco and Los Angeles face off again on Sunday. Here's what to know about one of the oldest rivalries ...

Everything you need to know about the Rams' home game against the NFC West rival San Francisco 49ers, including start time, ...

Jimmy Garoppolo knows what it feels like as a San Francisco 49er to come to L.A., but now the quarterback is on the other ...

San Francisco 49ers wide receiver Deebo Samuel will be sidelined the next couple of weeks because of a calf strain he endured ...

NFL Week 3 odds, picks, predictions, TV and streaming information for the Sunday football game between the San Francisco ...

This is the live blog for the San Francisco 49ers' Week 2 road game against the Minnesota Vikings. This will be updated ...

In June, Jefferson signed a record-setting deal with Minnesota. The four-year, $140 million contract extension made Jefferson ...