Most discontinued anti-tau antibodies (red) targeted tau’s N-terminus. Of the antibodies currently in trials (green), bepranemab and E2814 presented results at CTAD, while JJ-63733657/posdinemab and ...

Taking Out OGA. The rationale behind small-molecule OGA inhibition is that these drugs will decrease tau hyperphosphorylation ...

An estimated 4,500 prescriptions have been filled in 2024 so far, Iwatsubo said. About 80 percent of patients have mild cognitive impairment, the rest have mild dementia. Most are in their 70s, and ...

In recent years, CryoEM has enabled scientists to decipher the structures of the fibrils that form various deposits in neurodegenerative disease. They have not only solved disease-specific folding ...

Scientists in industry and academia were shocked and saddened to hear of the sudden passing of Bruce Albala. Albala died in Greece on October 16 while celebrating his 40th wedding anniversary with his ...

PhD, National University of Singapore Postdoctoral fellow, University of Oxford Postdoctoral fellow, National Institutes of Health ...

Multiple due dates; see announcement.

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.