BACH1 - Wikipedia
Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene. [5][6][7] This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip).
Bach1: Function, Regulation, and Involvement in Disease
Oct 2, 2018 · The transcription factor BTB and CNC homology 1 (Bach1) is widely expressed in most mammalian tissues and functions primarily as a transcriptional suppressor by heterodimerizing with small Maf proteins and binding to Maf recognition elements in the promoters of targeted genes.
BACH1 Gene - GeneCards | BACH1 Protein | BACH1 Antibody
Dec 24, 2024 · BACH1 (BTB Domain And CNC Homolog 1) is a Protein Coding gene. Diseases associated with BACH1 include Beta-Thalassemia and Breast Cancer. Among its related pathways are Nuclear events mediated by NFE2L2 and Cellular responses to stimuli.
Transcription factor BACH1 in cancer: roles, mechanisms, and …
BACH1 has different functions in the regulation of apoptosis in the progression of cancer (Fig. 5). BACH1 is highly expressed in lung CSCs, where it increases the expression of BCL-2 protein and represses the expression of BAX as well as p53, thereby inhibiting apoptosis .
Bach1: Function, Regulation, and Involvement in Disease
Oct 2, 2018 · The transcription factor BTB and CNC homology 1 (Bach1) is widely expressed in most mammalian tissues and functions primarily as a transcriptional suppressor by heterodimerizing with small Maf proteins and binding to Maf recognition elements in the promoters of targeted genes.
Transcription factor BACH1 in cancer: roles, mechanisms, and …
Feb 7, 2024 · Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap 'n' Collar and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates epigenetic modifications, heme homeostasis, and …
BACH1 controls hepatic insulin signaling and glucose ... - Nature
Dec 21, 2023 · Hepatocyte-specific Bach1 deletion in male mice on a high-fat diet (HFD) ameliorates hyperglycemia and insulin resistance, improves glucose homeostasis, and protects against steatosis, whereas...
BACH1 Is a Specific Repressor of - PubMed Central (PMC)
Here, we investigate the effect of BACH1 inactivation on the induction of HMOX1 and as a mechanism for broader gene induction. We show that BACH1 is inactivated at low micromolar arsenite concentrations and that BACH1 inactivation is necessary and sufficient for transcriptional induction of HMOX1.
Regulatory mechanisms of heme regulatory protein BACH1: a …
Sep 4, 2021 · This review discusses the current knowledge about how BACH1 regulates cancer metastasis in various types of cancer and other carcinogenic associated factors such as oxidative stress, cell cycle regulation, apoptosis, and angiogenesis.
BACH1 - an overview | ScienceDirect Topics
BACH1 controls the gene transcription through forming a heterodimer with small Maf family. • BACH1 is a heme-binding transcription factor and known as a repressor of HMOX1. • BACH1 is involved in heme degradation, redox regulation, cell cycle, apoptosis pathways and subcellular transport processes. •